Observations on Some Immunological Aspects of Leptospira Icterohæmorrhagiæ
نویسنده
چکیده
Active immunization against leptospiral infection was first demonstrated by Ido et al. (1916). They successfully immunized guineapigs with killed leptospira in the liver emulsions of infected guinea-pigs. Noguchi (1918) employed leptospira cultures instead of infected liver emulsion, and found that the inoculation of the killed cultures in sufficient quantities afforded complete protection to the same animals against a subsequent infection with virulent cultures of both homologous and heterologous strains. On account of the encouraging results obtained with guinea-pigs, miners in Japan have been inoculated with killed cultures and satisfactory protection results claimed. For example, Wani (1933) inoculated several miners and noted that in one mine and during the same period five cases occurred among 3,655 vaccinated and 70 among 6,266 non-vaccinated miners.
منابع مشابه
Studies on Leptospira Icterohæmorrhagiæ in Rats in Bombay City
mouse. These workers, acting on this suggestion, examined a number of wild rats. The presence of similar spirochetes were detected in the kidney or urine of the rats and were also demonstrated by means of guinea-pig inoculations. Since then, investigations have been carried out in different parts of the world by different workers. High prevalence of infection among rats has been observed both i...
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or by a single dose of 2 c.cm. of rich live culture followed 24 hours after by 0.25 c.cm. of immune rabbit serum given intraperitoneally. The latter procedure was found to be a very efficient and quick method of immunizing guinea-pigs against leptospiral infection. The sera of these animals agglutinated the homologous strain in a dilution of 1 : 10,000 in every case. This titre had not decrease...
متن کاملThe Survival of Leptospira (spirochæta) Icterohæmorrhagiæ in Nature; Observations concerning Microchemical Reactions and Intermediary Hosts
1. Leptospira icterohaemorrhagiae is unable to grow in the urine, either with or without the addition of suitable culture ingredients, the acidity of the urine being detrimental to the growth. It survives less than 24 hours, unless the urine is neutralized or slightly alkalized, when the period of survival is somewhat longer. If suitable nutrient ingredients are added to the neutralized or slig...
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عنوان ژورنال:
دوره 77 شماره
صفحات -
تاریخ انتشار 1942